(1R,5S,6r)-rel-3-Boc-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane
exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol
CAS: 419572-18-2
Molecular Formula: C11H19NO3
(1R,5S,6r)-rel-3-Boc-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane - Names and Identifiers
(1R,5S,6r)-rel-3-Boc-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane - Physico-chemical Properties
| Molecular Formula | C11H19NO3 |
| Molar Mass | 213.27 |
| Density | 1.157 |
| Boling Point | 308℃ |
| Flash Point | 140℃ |
| pKa | 14.94±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Irritant |
| MDL | MFCD14525755 |
(1R,5S,6r)-rel-3-Boc-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane - Risk and Safety
| Hazard Class | IRRITANT |
(1R,5S,6r)-rel-3-Boc-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane - Introduction
exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol (exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol) is an organic compound having the following properties:
Appearance: white crystalline solid
Molecular formula: C11H19NO3
Molecular weight: 217.27g/mol
Melting point: 78-80°C
Boiling point: 280-290°C
solubility: soluble in ethanol, chloroform, slightly soluble in water
Use of this compound:
1. As an intermediate in organic synthesis, it is often used to synthesize target molecules with pharmaceutical activity.
2. Used as selective masking reagent in drug research.
Preparation Method:
exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol are prepared as follows:
First, 2.5-dimethylamino-1-methylcyclopropan-1-ol and phthalimide are reacted to obtain exo-3-(hydroxymethyl)-3-azabicyclo [3.1.0] hexane. exo-3-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane is then reacted with tert-butyryl chloride to produce exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol.
Safety Information:
This compound may be harmful to the human body. Appropriate laboratory operation measures and protective measures should be taken, and relevant safety operation procedures should be followed. During handling and storage, the compound should be handled properly to avoid contact with strong oxidants and ignition sources. If the skin or eyes are touched, rinse immediately with plenty of water and seek medical help.
Appearance: white crystalline solid
Molecular formula: C11H19NO3
Molecular weight: 217.27g/mol
Melting point: 78-80°C
Boiling point: 280-290°C
solubility: soluble in ethanol, chloroform, slightly soluble in water
Use of this compound:
1. As an intermediate in organic synthesis, it is often used to synthesize target molecules with pharmaceutical activity.
2. Used as selective masking reagent in drug research.
Preparation Method:
exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol are prepared as follows:
First, 2.5-dimethylamino-1-methylcyclopropan-1-ol and phthalimide are reacted to obtain exo-3-(hydroxymethyl)-3-azabicyclo [3.1.0] hexane. exo-3-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane is then reacted with tert-butyryl chloride to produce exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol.
Safety Information:
This compound may be harmful to the human body. Appropriate laboratory operation measures and protective measures should be taken, and relevant safety operation procedures should be followed. During handling and storage, the compound should be handled properly to avoid contact with strong oxidants and ignition sources. If the skin or eyes are touched, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 21:21:28
![(1R,5S,6r)-rel-3-Boc-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane](http://res.chembk.com/assets/images/structure/419572-18-2.gif)